|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_071386, 38524600|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||70161 Da|
|Application Notes||MIPU1 antibody can be used for detection of MIPU1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||MIPU1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||MIPU1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transcriptional regulation.|
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Provided below are standard protocols that you may find useful for product applications.
MIPU1 Antibody: Mipu1, also known as zinc finger protein 667 or ZNF667, encodes a nuclear-localized protein containing 14 carboxy-terminal zinc finger motifs and an amino-terminal KRAB domain. This protein is highly expressed in heart and brain and is upregulated in rat heart after a transient ischemia-reperfusion procedure. Overexpression experiments suggest that Mipu1 suppresses the transcriptional activities of AP-1 and SRE in the MAPK signaling pathway and thus may play a role in the pathogenesis of cardiac and vascular disease. At least four isoforms of MIPU1 are known to exist.
Jiang L, Tang D, Wang K, et al. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. Biochem. Biophys. Res. Commun.2007; 356:829-35.
Wang G, Zuo X, Jiang L, et al. Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene. Braz. J. Biol. Res.2009; epub.
Yuan C, Zhang HL, Liu Y, et al. Cloning and characterization of a new gene Mipu1 up-regulated during myocardial ischemia-reperfusion. Prog. Biochem. Biophys.2004; 31:231-6.
Wang G, Zuo X, Yuan C, et al. Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway. Mol. Cell. Biochem.2009; 322:93-102.
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