Prosapip1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | O60299 |
Other Accession | NP_055546, 7662176 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 71791 Da |
Application Notes | Prosapip1 antibody can be used for detection of Prosapip1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
Gene ID | 9762 |
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Target/Specificity | ProSAPiP1; |
Reconstitution & Storage | Prosapip1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | Prosapip1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LZTS3 (HGNC:30139) |
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Function | May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. |
Cellular Location | Synapse {ECO:0000250|UniProtKB:Q8K1Q4}. Postsynaptic density {ECO:0000250|UniProtKB:Q8K1Q4}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8K1Q4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8K1Q4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K1Q4}. Note=Rather found at excitatory than inhibitory synapses. {ECO:0000250|UniProtKB:Q8K1Q4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Prosapip1 Antibody: Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3's PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.
References
Wendholt D, Spilker C, Schmitt A, et al. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein proSAP2/Shank3. J. Biol. Chem.2006; 281:13805-16.
Redecker P, Bockmann J, and Bockers TM. Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density. Cell Tissue Res.2007; 328:49-55.
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