IA-6 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q96T92 |
Other Accession | AAI30380, 120659844 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 59491 Da |
Application Notes | IA-6 antibody can be used for detection of IA-6 by Western blot at 1 - 2 µg/mL. |
Gene ID | 84684 |
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Target/Specificity | INSM2; |
Reconstitution & Storage | IA-6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | IA-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INSM2 |
---|---|
Synonyms | IA6 |
Function | May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. |
Cellular Location | Cytoplasm. Nucleus. |
Tissue Location | Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
IA-6 Antibody: IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription.
References
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet.2004; 36:40-5.
Wildner H, Gierl MS, Strehle M, et al. Insm (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympathoadrenal lineage. Dev.2008; 135:473-81.
Trembleau S, Penna G, Grigori S, et al. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J. Immunol.2000; 165:6748-55.
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