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SIPA1L2 Antibody

  • IHC - SIPA1L2 Antibody ASC11019
    Immunohistochemistry of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 5 µg/mL.
  • IF - SIPA1L2 Antibody ASC11019
    Immunofluorescence of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 20 µg/mL.
  • WB - SIPA1L2 Antibody ASC11019
    Western blot analysis of SIPA1L2 in rat brain tissue lysate with SIPA1L2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P2F8
Other Accession NP_065859, 112421013
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 190438 Da
Application Notes SIPA1L2 antibody can be used for detection of SIPA1L2 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 57568
Target/Specificity SIPA1L2;
Reconstitution & Storage SIPA1L2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSIPA1L2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIPA1L2
Synonyms KIAA1389
Research Areas
Citations (0)

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SIPA1L2 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L2) is a member of the SIPA1 family of RapGAPs. Little is known of the role of the SIPA1L2 protein, but recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is likely that SIPA1L2 plays a role in embryo development and cell proliferation, possibly including oncogenesis.


Minato N and Hattori M. SPA-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Sci.2009; 100:17-23.
Ishida D, Kometani K, Yang H, et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell2003; 4:55-65.
Park YG, Zhao X, Lesueur F, et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus, Mtes. Nat. Genet.2005; 37:1055-62.
Tsai I-C, Amack JD, Gao Z-H, et al. A Wnt-CKI e-Rap1 pathway regulates gastrulation by modulating SIPA1L2, a Rap GTPase activating protein. Dev. Cell2007; 12:335-47.

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$ 310.00
Cat# ASC11019
(40 western blots)
Availability: 5-7days
Bulk Size
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