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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SIPA1L3 Antibody   

SIPA1L3 Antibody

  • WB - SIPA1L3 Antibody ASC11020
    Western blot analysis of SIPA1L3 in SK-N-SH lysate with SIPA1L3 antibody at 1 µg/mL.
  • IHC - SIPA1L3 Antibody ASC11020
    Immunohistochemistry of SIPA1L3 in human brain tissue with SIPA1L3 antibody at 5 µg/mL.
  • IF - SIPA1L3 Antibody ASC11020
    Immunofluorescence of SIPA1L3 in Human Brain cells with SIPA1L3 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60292
Other Accession NP_055888, 71143119
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 194610 Da
Application Notes SIPA1L3 antibody can be used for detection of SIPA1L3 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 23094
Target/Specificity SIPA1L3;
Reconstitution & Storage SIPA1L3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSIPA1L3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIPA1L3
Synonyms KIAA0545, SPAL3
Function Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217).
Cellular Location Apical cell membrane. Note=Detected in tricellular junctions. Colocalizes with apical F-actin
Research Areas
Citations (0)

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SIPA1L3 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.


Minato N and Hattori M. SPA-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Sci.2009; 100:17-23.
Matsuda M, Kobayashi Y, Masuda S, et al. Identification of adherences junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Exp. Cell Res.2008; 314:939-49.
Ishida D, Kometani K, Yang H, et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell2003; 4:55-65.
Park YG, Zhao X, Lesueur F, et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus, Mtes. Nat. Genet.2005; 37:1055-62.

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$ 330.00
Cat# ASC11020
Availability: 5-7days
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