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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPAPDC2 Antibody   

PPAPDC2 Antibody

  • WB - PPAPDC2 Antibody ASC11028
    Western blot analysis of PPAPDC2 in Raji cell lysate with PPAPDC2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IF - PPAPDC2 Antibody ASC11028
    Immunofluorescence of PPAPDC2 in Raji cells with PPAPDC2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IY26
Other Accession NP_982278, 66773040
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32194 Da
Application Notes PPAPDC2 antibody can be used for detection of PPAPDC2 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 403313
Target/Specificity PPAPDC2;
Reconstitution & Storage PPAPDC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsPPAPDC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLPP6 (HGNC:23682)
Synonyms PPAPDC2
Function Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.
Research Areas
Citations (0)

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PPAPDC2 Antibody: PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.


Fukunaga K, Arita M, Takahashi M, et al. Identification and functional characterization of a presqualene diphosphate phosphatase. J. Biol. Chem.2006; 281:9490-7.
Miriyala S, Subramanian T, Panchatcharam M, et al. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. J. Biol. Chem.2010 (epub).

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$ 330.00
Cat# ASC11028
Availability: 5-7days
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