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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TMEM38B Antibody   

TMEM38B Antibody

     
  • WB - TMEM38B Antibody ASC11031
    Western blot analysis of TMEM38B in rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - TMEM38B Antibody ASC11031
    Immunohistochemistry of TMEM38B in mouse thymus tissue with TMEM38B antibody at 5 µg/mL.
  • IF - TMEM38B Antibody ASC11031
    Immunofluorescence of TMEM38B in mouse thymus tissue with TMEM38B antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9NVV0
Other Accession NP_060582, 8922461
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32510 Da
Application Notes TMEM38B antibody can be used for detection of TMEM38B by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 55151
Target/Specificity TMEM38B;
Reconstitution & Storage TMEM38B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTMEM38B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM38B
Synonyms C9orf87
Function Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

TMEM38B Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

References

Yazawa M, Ferrante C, Feng J, et al. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature2007; 448:78-82.
Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther.2009; 121:265-72.
Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther.2009; 121:265-72.

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$ 320.00
Cat# ASC11031
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