|Application ||WB, E|
|Other Accession||NP_060512, 157388955|
|Calculated MW||66972 Da|
|Application Notes||SLFN12 antibody can be used for detection of SLFN12 by Western blot at 1 µg/mL.|
|Reconstitution & Storage||SLFN12 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||SLFN12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
SLFN12 Antibody: Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.
Schwarz DA, Katamaya CD, and Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity1998; 9:657-68.
Bustos O, Naik S, Ayers G, et al. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Gene2009; 447:1-11.
Condamine T, Le Laduec J-B, Chiffoleau E, et al. Characterization of Schlafen-3 expression in effector and regulatory T cells. J. Leuk. Biol.2010; 87:1-6.
Cusco I, del Campo M, Vilardell M, et al. Array-CGH in patients with Kabuki-like phenotype: Identification of two patients with complex rearrangements including 2q37 deletions and no other recurrent aberration. BMC Med. Gen.2008; 9:27.
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