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SLFN14 Antibody

     
  • WB - SLFN14 Antibody ASC11037
    Western blot analysis of SLFN14 in mouse kidney tissue lysate with SLFN14 antibody at (A) 1 and (B) 2 µg/mL.
  • IF - SLFN14 Antibody ASC11037
    Immunofluorescence of SLFN14 in mouse kidney tissue with SLFN14 antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession P0C7P3
Other Accession NP_001123292, 193788705
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 103907 Da
Application Notes SLFN14 antibody can be used for detection of SLFN14 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 342618
Target/Specificity SLFN14;
Reconstitution & Storage SLFN14 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSLFN14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLFN14 (HGNC:32689)
Function Protein SLFN14: Shows no ribosome-associated and endoribonuclease activities.
Cellular Location Protein SLFN14: Nucleus
Tissue Location Expressed in megakaryocytes and platelets (at protein level) (PubMed:26280575). Weakly expressed in melanocytes and malignant melanoma cells (PubMed:20956525)
Research Areas
Citations (0)

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Background

SLFN14 Antibody: Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. SLFN14 is a recently identified member of the SLFN family; its role has yet to be determined.

References

Schwarz DA, Katamaya CD, and Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity1998; 9:657-68.
Bustos O, Naik S, Ayers G, et al. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Gene2009; 447:1-11.

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$ 320.00
Cat# ASC11037
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