|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_079047, 189571650|
|Calculated MW||27194 Da|
|Application Notes||NAT11 antibody can be used for detection of NAT11 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||NAT11 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||NAT11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.|
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Provided below are standard protocols that you may find useful for product applications.
NAT11 Antibody: N-terminal acetylation is one of the most common protein modifications in eukaryotes, occurring on approximately 57% and 84% on yeast and human proteins respectively. There are several N-terminal acetylating enzyme complexes (NatA - NatE). Unlike the other complexes, NatD is composed of a single protein, NAT11, and has recently been described to acetylate the Serine N-termini of histones H2A and H4 in yeast. The role these modifications play is unknown; yeast that do not express NAT11 grow at normal rates and have no observable phenotypes. The role of the human homolog is likewise unknown.
Arnesen T, Van Damme P, Polevoda B, et al. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc. Natl. Acad. Sci. USA2009; 106:8157-62.
OK Song, Wang X, Waterborg JH, et al. An Nalpha-acetyl-transferase responsible for acetylation of the N-terminal residues of histones H4 and H2A. J. Biol. Chem.2003; 278:38109-1
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