SYNGR3 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | O43761 |
Other Accession | NP_004200, 6631112 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 24555 Da |
Application Notes | SYNGR3 antibody can be used for detection of SYNGR3 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
Gene ID | 9143 |
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Target/Specificity | SYNGR3; |
Reconstitution & Storage | SYNGR3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | SYNGR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYNGR3 (HGNC:11501) |
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Function | May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R191}; Multi-pass membrane protein. Synapse {ECO:0000250|UniProtKB:Q8R191} Note=Found at the neuromuscular synapses {ECO:0000250|UniProtKB:Q8R191} |
Tissue Location | Expressed in brain and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SYNGR3 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. SYNGR3 is predominantly expressed in brain and placenta. SYNGR3 is involved in the positive regulation of dopamine transporter activity and facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release.
References
Belizaire R, Komanduri C, Wooten K, et al. Characterization of synaptogyrin 3 as a new synaptic vesicle protein. J. Comp. Neurol.2004; 470:266-81.
Egaña LA, Cuevas RA, Baust TB, et al. Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J. Neurosci.2009; 29:4592-604.
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