|Application ||WB, IHC-P, E|
|Other Accession||CAJ86451, 90403050|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||94719 Da|
|Application Notes||LZTR1 antibody can be used for detection of LZTR1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.|
|Reconstitution & Storage||LZTR1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||LZTR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcriptional regulator that may play a crucial role in embryogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
LZTR1 Antibody: LZTR1, a member of the BTB-kelch superfamily, was initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Golgi complex. Deletion of this gene may be associated with DiGeorge syndrome, a developmental field defect involving the third and fourth pharyngeal pouches, causing the absence of thymus and parathyroid glands, congenital cardiac abnormalities and facial dysmorphism. LZTR1 is tyrosine phosphorylated and subsequently degraded upon induction of apoptosis.
Kurahashi H, Akagi K, Inazawa J, et al. Isolation and characterization of a novel gene deleted in DiGeorge syndrome. Hum. Mol. Genet.1995; 4:541-9.
Nacak TG, Leptien K, Fellner D, et al. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis. J. Biol. Chem.2006; 281:5065-71.
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