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TMEM70 Antibody

  • WB - TMEM70 Antibody ASC11085
    Western blot analysis of TMEM70 in human liver tissue lysate with TMEM70 antibody at 1 µg/mL.
  • IHC - TMEM70 Antibody ASC11085
    Immunohistochemistry of TMEM70 in rat liver tissue with TMEM70 antibody at 5 µg/mL.
  • IF - TMEM70 Antibody ASC11085
    Immunofluorescence of TMEM70 in rat liver tissue with TMEM70 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BUB7
Other Accession NP_060336, 34147498
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 28969 Da
Application Notes TMEM70 antibody can be used for detection of TMEM70 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 54968
Target/Specificity TMEM70;
Reconstitution & Storage TMEM70 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTMEM70 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM70
Function Involved in biogenesis of mitochondrial ATP synthase.
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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TMEM70 Antibody: TMEM70 is a recently identified mitochondrial protein that is thought to play a role in the biogenesis of the ATP synthase in higher eukaryotes. Mutations in this gene result in early neonatal onset of hypotonia, hypertrophic cardiomyopathy, lactic acidos and 3-methylglutaconic aciduria (3-MGC-uria), and usually cause death within the first six weeks of life, although some patients survive much longer. Little is known of the role of TMEM70, but it is conserved across multicellular eukaryotic organisms. It contains a conserved DUF1301 domain and two putative transmembrane regions.


Cizkova A, Stranecky V, Mayr JA, et al. TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat. Genet.2008; 11:1288-90.
Honzik T, Tesarova M, Mayr JA, et al. Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation. Arch. Dis. Child.2010; 95:296-301.
Houstek J, Kmoch S, and Zeman J. TMEM70 protein - a novel ancillary factor of mammalian ATP synthase. Biochim. Biophys. Acta2009; 1787:529-32.

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$ 330.00
Cat# ASC11085
Availability: 5-7days
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