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MYBPC2 Antibody

  • WB - MYBPC2 Antibody ASC11088
    Western blot analysis of MYBPC2 in mouse skeletal muscle tissue lysate with MYBPC2 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - MYBPC2 Antibody ASC11088
    Immunohistochemistry of MYBPC2 in mouse skeletal muscle tissue with MYBPC2 antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14324
Other Accession EAW71866, 119592272
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 128072 Da
Application Notes MYBPC2 antibody can be used for detection of MYBPC2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 4606
Target/Specificity MYBPC2;
Reconstitution & Storage MYBPC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsMYBPC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MYBPCF
Function Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Research Areas
Citations (0)

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MYBPC2 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the fast-type isoform designated MYBPC2. Both the fast-type and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. MYBPC2 is typically required for strong contractions and functions under anaerobic conditions. It is more similar to the cardiac isoform (MYBPC3) than to the slow-type isoform (MYBPC1) in terms of pCa50-indexed force development, length-independent cooperativity and length dependent activation. It has been suggested that in cardiac and fast muscle MYBPC2 contributes to an internal load, possibly by binding to actin via its N-terminal region.


Weber FE, Vaughan KT, Reiach FC, et al. Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. Eur. J. Biochem.1993; 216:661-9.
Konhilas JP, Irving TC and De Tombe PP. Length-dependent activation in three striated muscle types of the rat. J. Physiol.2002; 544:225-36.
Flashman E, Korkie L, Watkins H, et al. Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle. FEBS Lett.2008; 582:434-8.

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$ 310.00
Cat# ASC11088
(40 western blots)
Availability: 5-7days
Bulk Size
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