|Application ||WB, IHC-P, IF, E|
|Other Accession||EAW66844, 119587248|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||14282 Da|
|Application Notes||LYRM1 antibody can be used for detection of LYRM1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||LYRM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||LYRM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May promote cell proliferation and inhibition of apoptosis of preadipocytes.|
|Tissue Location||High levels in adipose tissue.|
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Provided below are standard protocols that you may find useful for product applications.
LYRM1 Antibody: LYRM1 was one of many genes identified through a suppression subtractive hybridization comparing their expression in omental adipose tissue of obese patients compared to non-obese individuals. Further study confirms that both mRNA and protein levels of LYRM1 are higher in obese individuals. LYRM1 is widely expressed, with highest levels occurring in adipose and liver tissues. It is thought that LYRM1 promotes preadipocyte proliferation and can inhibit apoptosis of preadipocytes. Ectopic LYRM1 expression did not significantly affect adipogenesis, suggesting that LYRM1 can influence adipose tissue homeostasis by modulating the size of the preadipocyte pool.
Qiu J, Ni YH, Gong HX, et al. Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization. Biochem. Biophys. Res. Comm.2007; 352:469-78.
Qiu J, Gao CL, Zhang M, et al. LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes. Eur. J. Endocrinol.2009; 160:177-84.
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