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TMEM184A Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6ZMB5 |
| Other Accession | NP_001091089, 202915 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 45777 Da |
| Application Notes | TMEM184A antibody can be used for detection of TMEM184A by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. |
| Gene ID | 202915 |
|---|---|
| Target/Specificity | TMEM184A antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TMEM184A. The immunogen is located within the last 50 amino acids of TMEM184A. |
| Reconstitution & Storage | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TMEM184A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM184A |
|---|---|
| Function | Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q4QQS1}; Multi-pass membrane protein. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q4QQS1}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q1RMW2}; Multi-pass membrane protein. Early endosome membrane {ECO:0000250|UniProtKB:Q3UFJ6}; Multi-pass membrane protein. Endosome {ECO:0000250|UniProtKB:Q3UFJ6}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q3UFJ6} |
| Tissue Location | Expressed in vascular cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
TMEM184A Antibody: TMEM184A, a multi-pass transmembrane protein, belongs to the UPF0206 family. While the exact function of TMEM184A remains unclear, it is known to be expressed at high levels in the developing testis. TMEM184A may mediate sex-specific signaling events during Sertoli cell differentiation. The restricted expression of this gene in Sertoli cells suggests a role for the encoded protein in the development and/or continued function of that cell type. Ectopic expression of TMEM184A in female genital ridges resulted in failure of gonocytes to enter meiosis.
References
Svingen T, Beverdam A, Bernard P, et al. Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction2007; 133:983-9.
Svingen T, Wilhelm D, Combes AN, et al. Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis. Dev Dyn.2009; 238:956-64.
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