|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_056436, 45935391|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||34796 Da|
|Application Notes||CCDC69 antibody can be used for detection of CCDC69 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||CCDC69 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||CCDC69 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.|
|Cellular Location||Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.|
|Tissue Location||Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder|
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Provided below are standard protocols that you may find useful for product applications.
CCDC69 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. The CCDC47 gene maps to chromosome 5 at 5q33.1. Little is known about this protein.
Steinmetz MO, Jelesarov I, Matousek WM, et al. Molecular basis of coiled-coil formation. Proc. Natl. Acad. Sci. USA2007; 104:7062-7.
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