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TCC52 Antibody

  • WB - TCC52 Antibody ASC11110
    Western blot analysis of TCC52 in 293 cell lysate with TCC52 antibody at 1 µg/mL.
  • ICC - TCC52 Antibody ASC11110
    Immunocytochemistry of TCC52 in 293 cells with TCC52 antibody at 2.5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5T6F0
Other Accession NP_056212, 22218619
Reactivity Human, Mouse, Rat
Host Chicken
Clonality Polyclonal
Isotype IgY
Calculated MW 50517 Da
Application Notes TCC52 antibody can be used for detection of TCC52 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL.
Additional Information
Gene ID 25853
Target/Specificity DCAF12;
Reconstitution & Storage TCC52 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTCC52 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCAF12
Synonyms KIAA1892, TCC52, WDR40A
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Tissue Location Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis
Research Areas
Citations (0)

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TCC52 Antibody: Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.


Scanlan M, Simpson A, and Old L. The cancer/testis genes: review, standardization, and commentary. Cancer Immun.2004; 4:1-15.
Xia L, Li Y, Yang D, et al. Identification of new centrosome proteins by autoimmune patient sera. Sci. China C. Life Sci.2007; 50:194-202.
Li S, Hu X, Cui S, et al. Novel centrosome protein, TCC52, is a cancer-testis antigen. Cancer Sci.2008; 11:2274-9.

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$ 310.00
Cat# ASC11110
(40 western blots)
Availability: 5-7days
Bulk Size
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