|Application ||WB, ICC, E|
|Other Accession||NP_056212, 22218619|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||50517 Da|
|Application Notes||TCC52 antibody can be used for detection of TCC52 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL.|
|Reconstitution & Storage||TCC52 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||TCC52 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1892, TCC52, WDR40A|
|Function||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
|Tissue Location||Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis|
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Provided below are standard protocols that you may find useful for product applications.
TCC52 Antibody: Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.
Scanlan M, Simpson A, and Old L. The cancer/testis genes: review, standardization, and commentary. Cancer Immun.2004; 4:1-15.
Xia L, Li Y, Yang D, et al. Identification of new centrosome proteins by autoimmune patient sera. Sci. China C. Life Sci.2007; 50:194-202.
Li S, Hu X, Cui S, et al. Novel centrosome protein, TCC52, is a cancer-testis antigen. Cancer Sci.2008; 11:2274-9.
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