CaBP8 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BXU9 |
Other Accession | NP_113656, 157743275 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 29324 Da |
Application Notes | CaBP8 antibody can be used for detection of CaBP8 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL. |
Gene ID | 83698 |
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Target/Specificity | CALN1; |
Reconstitution & Storage | CaBP8 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | CaBP8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CALN1 |
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Synonyms | CABP8 |
Function | Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. |
Cellular Location | Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein |
Tissue Location | Brain specific.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CaBP8 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
References
Sokal I, Li N, Verlinde CL, et al. Ca2+-binding proteins in the retina: from discovery to etiology of human disease. Biochim. Biophys. Acta.2000; 1498: 233-51.
Haeseleer F, Imanishi Y, Sokal I, et al. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem. Biophys. Res. Commun.2002; 290:615-23.
Ikura M, Osawa M, and Ames JB. The role of calcium-binding proteins in the control of transcription: structure to function. Bioessays2002; 24:625-36.
McCue HV, Burgoyne RD, Haynes LP. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. Biochem. Biophys. Res. Commun.2009; 380:825-31.
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