VENTX Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | O95231 |
Other Accession | NP_055283, 7657180 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 27552 Da |
Application Notes | VENTX antibody can be used for detection of VENTX by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
Gene ID | 27287 |
---|---|
Target/Specificity | VENTX; |
Reconstitution & Storage | VENTX antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | VENTX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | VENTX |
---|---|
Synonyms | HPX42B, VENTX2 |
Function | May be involved in ventralization. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line |
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Provided below are standard protocols that you may find useful for product applications.
Background
VENTX Antibody: Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. VENTX is a member of the Vent family of homeodomain proteins. It is a novel LEF/TCF-associated transcriptional modulator. VENTX is predominately expressed in hematopoietic cells. VENTX may function as a transcriptional repressor and be involved in mesodermal patterning and hemapoietic stem cell maintenance, and has been suggested to have a potential role in the hematopoietic malignancies.
References
Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature2005; 434:843-50.
Moretti PA, Davidson AJ, Baker E, et al. Molecular cloning of a human Vent-like homeobox gene. Genomics2001; 76:21-9.
Gao H, Le Y, Wu X, et al. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res.2010; 70:202-11.
Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA1999; 96:5522-7.
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