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SESTD1 Antibody

  • WB - SESTD1 Antibody ASC11182
    Western blot analysis of SESTD1 in rat brain tissue lysate with SESTD1 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - SESTD1 Antibody ASC11182
    Immunohistochemistry of SESTD1 in human brain tissue with SESTD1 antibody at 5 µg/mL.
  • IF - SESTD1 Antibody ASC11182
    Immunofluorescence of SESTD1 in Human Brain cells with SESTD1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86VW0
Other Accession NP_835224, 188528641
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 79348 Da
Application Notes SESTD1 antibody can be used for detection of SESTD1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 91404
Target/Specificity SESTD1;
Reconstitution & Storage SESTD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSESTD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SOLO
Function May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
Tissue Location Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature
Research Areas
Citations (0)

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SESTD1 Antibody: SESTD1 was initially identified in mutant zebrafish with defects in the spontaneous contraction and touch response as a novel gene, solo, encoding a protein containing SEC14 and spectrin repeat domains. Other experiments indicated that SESTD1 interacts with the TRPC4 and TRPC5, members of the transient receptor potential channel family, via the TRPC calmodulin- and inositol 1, 4, 5-triphosphate receptor-binding domain and is essential for efficient receptor-mediated activation of TRPC5, suggesting that SESTD1 is a novel regulator of these TRPC proteins.


Sato T and Mishina M. Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. Genomics2003; 82:218-29.
Miehe S, Bieberstein A, Arnold I, et al. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J. Biol. Chem.2010; 285:12426-34.

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$ 310.00
Cat# ASC11182
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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