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WDR92 Antibody

     
  • WB - WDR92 Antibody ASC11184
    Western blot analysis of WDR92 in human kidney tissue lysate with WDR92 antibody at (A) 1 and (B) 2 µg/mL.
    detail
  • IHC - WDR92 Antibody ASC11184
    Immunohistochemistry of WDR92 in human testis tissue with WDR92 antibody at 10 µg/mL.
    detail
  • IF - WDR92 Antibody ASC11184
    Immunofluorescence of WDR92 in human testis tissue with WDR92 antibody at 20 µg/mL.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q96MX6
Other Accession NP_612467, 24308444
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 39740 Da
Application Notes WDR92 antibody can be used for detection of WDR92 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 116143
Target/Specificity WDR92;
Reconstitution & Storage WDR92 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsWDR92 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNAAF10 (HGNC:25176)
Synonyms WDR92
Function Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.
Cellular Location Dynein axonemal particle {ECO:0000250|UniProtKB:A8J3F6}
Tissue Location Widely expressed with the highest expression in testis.
Research Areas
Citations (0)
citation

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Background

WDR92 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR92, also known as monad, contains two WD40 repeats is widely expressed in human tissues, especially testis. Overexpression of this protein or its binding partner RNA polymerase II-associated protein 3 (RPAP3) potentiated apoptosis and caspase-3 activation induced by TNF-α and cycloheximide, suggesting that WDR92, together with RPAP3, may function as a novel modulator of apoptosis.

References

Saeki M, Irie Y, Ni L, et al. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha. Biochem. Biophys. Res. Commun.2006; 342:568-72.
Itsuki Y, Saeki M, Nakahara H, et al. Molecular cloning of novel Monad binding protein containing tetratricorticopeptide repeat domains. FEBS Lett.582:2365-70.

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$ 379.00
Cat# ASC11184
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