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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   NOD4 Antibody   

NOD4 Antibody

  • WB - NOD4 Antibody ASC11190
    Western blot analysis of NOD4 in EL4 cell lysate with NOD4 antibody at 1 µg/mL.
  • ICC - NOD4 Antibody ASC11190
    Immunocytochemistry of NOD4 in HeLa cells with NOD4 antibody at 10 µg/mL.
  • IF - NOD4 Antibody ASC11190
    Immunofluorescence of NOD4 in HeLa cells with NOD4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86WI3
Other Accession NP_115582, 116268109
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 205 kDa
Application Notes NOD4 antibody can be used for detection of NOD4 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84166
Target/Specificity NLRC5; NOD4 antibody is predicted to not cross-react with other members of the NOD family of proteins.
Reconstitution & Storage NOD4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNOD4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRC5
Synonyms NOD27, NOD4
Function Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
Cellular Location Cytoplasm
Tissue Location Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
Research Areas
Citations (0)

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NOD4 Antibody: NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-κB and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.


Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci. 2006; 1072:19-27.
Benko S, Magalhaes JG, Philpott DJ, et al. NLRC5 limits the activation of inflammatory pathways. J. Immunol. 2010; 185:1681-91.
Meissner TB, Li A, Biswas A, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. USA 2010; 107:13794-9.
Cui J, Zhu L, Xia X, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 2010; 141:483-96.

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$ 330.00
Cat# ASC11190
Availability: 5-7days
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