|Application ||WB, IF, ICC, E|
|Other Accession||NP_115582, 116268109|
|Calculated MW||205 kDa|
|Application Notes||NOD4 antibody can be used for detection of NOD4 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||NLRC5; NOD4 antibody is predicted to not cross-react with other members of the NOD family of proteins.|
|Reconstitution & Storage||NOD4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||NOD4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.|
|Tissue Location||Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
NOD4 Antibody: NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-κB and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci. 2006; 1072:19-27.
Benko S, Magalhaes JG, Philpott DJ, et al. NLRC5 limits the activation of inflammatory pathways. J. Immunol. 2010; 185:1681-91.
Meissner TB, Li A, Biswas A, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. USA 2010; 107:13794-9.
Cui J, Zhu L, Xia X, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 2010; 141:483-96.
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