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NALP5 Antibody

  • WB - NALP5 Antibody ASC11194
    Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - NALP5 Antibody ASC11194
    Immunohistochemistry of NALP5 in human brain tissue with NALP5 antibody at 10 µg/mL.
  • IF - NALP5 Antibody ASC11194
    Immunofluorescence of NALP5 in human brain tissue with NALP5 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P59047
Other Accession NP_703148, 158321897
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 134342 Da
Application Notes NALP5 antibody can be used for detection of NALP5 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 126206
Target/Specificity NLRP5;
Reconstitution & Storage NALP5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNALP5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP5
Synonyms MATER, NALP5
Function As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.
Cellular Location Mitochondrion. Nucleus, nucleolus. Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity).
Tissue Location Oocyte-specific.
Research Areas
Citations (0)

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NALP5 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.


Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Tong ZB, Gold L, Pfeiffer KE, et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat. Genet.2000; 26:267-8.
Frederick Lo C, Ning X, Gonzales C, et al. Induced expression of death domain genes NALP1 and NALP5 following neuronal injury. Biochem. Biophys. Res. Commun.2008; 366:664-9.

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$ 310.00
Cat# ASC11194
(40 western blots)
Availability: 5-7days
Bulk Size
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