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NALP6 Antibody

  • WB - NALP6 Antibody ASC11195
    Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IF - NALP6 Antibody ASC11195
    Immunofluorescence of NALP6 in human brain tissue with NALP6 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P59044
Other Accession NP_612202, 21264320
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 98768 Da
Application Notes NALP6 antibody can be used for detection of NALP6 by Western blot at 1 µg/mL. Antibody can also be used for immunoflourenscence starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 171389
Target/Specificity NLRP6;
Reconstitution & Storage NALP6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNALP6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP6
Synonyms NALP6, PYPAF5
Function May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus membrane
Tissue Location Highly expressed in granulocytes. Detected at much lower levels in T-cells
Research Areas
Citations (0)

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NALP6 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-κB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.


Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Grenier JM, Wang L, Manji GA, et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett.2002; 530:73-8.

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$ 310.00
Cat# ASC11195
(40 western blots)
Availability: 5-7days
Bulk Size
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