NALP14 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q86W24 |
Other Accession | NP_789792, 28827813 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 124733 Da |
Application Notes | NALP14 antibody can be used for detection of NALP14 by Western blot at 1 µg/mL. |
Gene ID | 338323 |
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Target/Specificity | NLRP14; |
Reconstitution & Storage | NALP14 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | NALP14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NLRP14 |
---|---|
Synonyms | NALP14, NOD5 {ECO:0000303|PubMed:1276675 |
Function | May be involved in inflammation and spermatogenesis. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q6B966}. |
Tissue Location | Testis-specific.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NALP14 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP14 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP14, it has been suggested that it may play a role in spermatogenesis and that mutations in the NALP14 gene might cause spermatogenic failure.
References
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Westerveld GH, Korver CM, van Pelt AMM, et al. Mutations in the tesits-specific NALP14 gene in men suffering from spermatogenic failure. Hum. Reprod.2006; 21:3178-84.
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