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ZNF346 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UL40 |
| Other Accession | NP_036411, 6912440 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 32933 Da |
| Application Notes | ZNF346 antibody can be used for detection of ZNF346 by Western blot at 1 µg/mL. |
| Gene ID | 23567 |
|---|---|
| Target/Specificity | ZNF346; |
| Reconstitution & Storage | ZNF346 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | ZNF346 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF346 |
|---|---|
| Synonyms | JAZ |
| Function | Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233). |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF346 Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.
References
Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep.2000; 1:287-92.
Yang M, May WS, and Ito T. JAZ requires the double-stranded RNA-binding zinc-finger motifs for nuclear localization. J. Biol. Chem.1999; 274: 27399-406.
Chen T, Brownawell AM, and Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for Exportin 5. Mol. Cell. Biol.2004; 24:6608-19.
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