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ZNF346 Antibody

  • WB - ZNF346 Antibody ASC11216
    Western blot analysis of ZNF346 in human kidney tissue lysate with ZNF346 antibody (A) 0.5 and (B) 1 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UL40
Other Accession NP_036411, 6912440
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32933 Da
Application Notes ZNF346 antibody can be used for detection of ZNF346 by Western blot at 1 µg/mL.
Additional Information
Gene ID 23567
Target/Specificity ZNF346;
Reconstitution & Storage ZNF346 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZNF346 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF346
Synonyms JAZ
Function Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.
Cellular Location Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5
Citations (0)

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ZNF346 Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.


Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep.2000; 1:287-92.
Yang M, May WS, and Ito T. JAZ requires the double-stranded RNA-binding zinc-finger motifs for nuclear localization. J. Biol. Chem.1999; 274: 27399-406.
Chen T, Brownawell AM, and Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for Exportin 5. Mol. Cell. Biol.2004; 24:6608-19.

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$ 310.00
Cat# ASC11216
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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