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MFSD1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H3U5 |
| Other Accession | NP_073573, 269847416 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 51209 Da |
| Application Notes | MFSD1 antibody can be used for detection of MFSD1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. |
| Gene ID | 64747 |
|---|---|
| Target/Specificity | MFSD1; |
| Reconstitution & Storage | MFSD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | MFSD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MFSD1 |
|---|---|
| Synonyms | SMAP4 |
| Function | Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP. |
| Cellular Location | Lysosome membrane {ECO:0000250|UniProtKB:Q9DC37}; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MFSD1 Antibody: Multidrug transporters, such as MFSD1, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that include uniporters, symporters, and antiporters. Members of this family are found in all living organisms and are highly represented in bacteria. MFS members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFS have provided important insight into the mechanism underlying multidrug transport. MFSD1 is still poorly understood.
References
Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.
Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.
Saidijam M, Benedetti G, Ren Q, et al. Microbial drug efflux proteins of the major facilitator superfamily. Curr. Drug Targets2006; 7:793-811.
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