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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   PIWI-L3 Antibody   

PIWI-L3 Antibody

  • WB - PIWI-L3 Antibody ASC11228
    Western blot analysis of PIWI-L3 in 3T3 cell lysate with PIWI-L3 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IF - PIWI-L3 Antibody ASC11228
    Immunofluorescence of PIWI-L3 in 3T3 cells with PIWI-L3 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z3Z3
Other Accession NP_001008496, 153792298
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 101089 Da
Application Notes PIWI-L3 antibody can be used for detection of PIWI-L3 by Western blot at 1 µg/mL. Antibody can also be used for immunofluorescence starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 440822
Target/Specificity PIWIL3;
Reconstitution & Storage PIWI-L3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsPIWI-L3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
Cellular Location Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis
Tissue Location Expressed in testis.
Research Areas
Citations (0)

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PIWI-L3 Antibody: PIWI-L3 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. Recent studies have shown that overexpression of PIWI-L3 (as well as other PIWI-like proteins) are potential biomarkers for astrocytic glioma, meningioma, and other cancers.


Sasaki T, Shiohama A, Minoshima S, et al. Identification of eight members of the Argonaute family in the human genome small star, filled. Genomics2003; 323-30.
Thomson T and Lin H. The biogenesis and function PIWI proteins and piRNAs: progress and prospect. Annu. Rev. Cell Dev. Biol.2009; 25:355-76.
Wang XL, Chen XM, Gao HJ, et al. Preparation and distribution of polyclonal antibodies against human PIWIL3 protein in tumor tissues. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008; 24:714-6.
Li L, Yu C, Gao H, et al. Argonaute proteins: potential biomarkers for human colon cancer. BMC Cancer2010; 10:38.

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$ 310.00
Cat# ASC11228
(40 western blots)
Availability: 5-7days
Bulk Size
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