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SYNPO2 Antibody

  • WB - SYNPO2 Antibody ASC11235
    Western blot analysis of SYNPO2 in human skeletal muscle tissue lysate with SYNPO2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - SYNPO2 Antibody ASC11235
    Immunohistochemistry of SYNPO2 in mouse skeletal muscle tissue with SYNPO2 antibody at 5 µg/mL.
  • IF - SYNPO2 Antibody ASC11235
    Immunofluorescence of SYNPO2 in mouse skeletal muscle tissue with SYNPO2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UMS6
Other Accession NP_597734, 193083183
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 117514 Da
Application Notes SYNPO2 antibody can be used for detection of SYNPO2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 171024
Target/Specificity SYNPO2;
Reconstitution & Storage SYNPO2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSYNPO2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Has an actin-binding and actin-bundling activity.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber- like pattern. partly overlapping with filamentous actin {ECO:0000250, ECO:0000269|PubMed:18371299}
Tissue Location Skeletal muscle specific.
Research Areas
Citations (0)

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SYNPO2 Antibody: SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.


Weins A, Schwarz K, Faul C, et al. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J. Cell Biol.2001; 155:393-404.
Shroeter MM, Beall B, Heid HW, et al. In vitro characterization of native mammalian smooth-muscle protein synaptopodin. Biosci. Rep.2008; 195-203.
Lin F, Yu YP, Woods J, et al. Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am. J. Path.2001; 5:1603-12.
De Ganck A, De Corte V, Bruyneel E, et al. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. Int. J. Oncol.2009; 34:1403-9.

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$ 330.00
Cat# ASC11235
Availability: 5-7days
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