|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_001073940, 122937343|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||110666 Da|
|Application Notes||PEAR1 antibody can be used for detection of PEAR1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||PEAR1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||PEAR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Note=Detected on the cell surface in resting platelets.|
|Tissue Location||Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages|
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Provided below are standard protocols that you may find useful for product applications.
PEAR1 Antibody: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.
Nanda N, Bao M, Lin H, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in the platelet contact-induced activation. J. Biol. Chem.2005; 280:24680-9.
Herrera-Galeano JE, Becker DM, Wilson AF, et al. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabili. Arterioscler. Thromb. Vasc. Biol.2008; 28:1484-90.
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