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ZBTB6 Antibody

     
  • WB - ZBTB6 Antibody ASC11263
    Western blot analysis of ZBTB6 in EL4 cell lysate with ZBTB6 antibody at 1 µg/mL.
  • ICC - ZBTB6 Antibody ASC11263
    Immunocytochemistry of ZBTB6 in EL4 cells with ZBTB6 antibody at 5 µg/mL.
  • IF - ZBTB6 Antibody ASC11263
    Immunofluorescence of ZBTB6 in EL4 cells with ZBTB6 antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, ICC, E
Primary Accession Q15916
Other Accession AAH37282, 5730122
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes ZBTB6 antibody can be used for detection of ZBTB6 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 5 µg/mL.
Additional Information
Gene ID 10773
Target/Specificity ZBTB6; At least two isoforms of ZBTB6 are known to exist; this antibody will only recognize the shorter isoform. This antibody is predicted to not cross-react with other ZBTB protein family members.
Reconstitution & Storage ZBTB6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZBTB6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBTB6
Synonyms ZID, ZNF482
Function May be involved in transcriptional regulation.
Cellular Location Nucleus.
Tissue Location Widely expressed with highest levels in brain. EMBL; X82018; CAA57543.1; -; mRNA EMBL; AK292401; BAF85090.1; -; mRNA EMBL; CH471090; EAW87552.1; -; Genomic_DNA EMBL; BC037282; AAH37282.1; -; mRNA CCDS; CCDS6846.1; - PIR; I39310; I39310 RefSeq; NP_006617.1; NM_006626.5 UniGene; Hs.654596; - ProteinModelPortal; Q15916; - SMR; Q15916; - BioGrid; 115991; 7 DIP; DIP-2653N; - IntAct; Q15916; 10 MINT; Q15916; - STRING; 9606.ENSP00000362763; - iPTMnet; Q15916; - PhosphoSitePlus; Q15916; - BioMuta; ZBTB6; - DMDM; 46577664; - EPD; Q15916; - MaxQB; Q15916; - PaxDb; Q15916; - PeptideAtlas; Q15916; - PRIDE; Q15916; - ProteomicsDB; 60817; - DNASU; 10773; - Ensembl; ENST00000373659; ENSP00000362763; ENSG00000186130 GeneID; 10773; - KEGG; hsa:10773; - UCSC; uc004bnh.5; human CTD; 10773; - EuPathDB; HostDB:ENSG00000186130.4; - GeneCards; ZBTB6; - HGNC; HGNC:16764; ZBTB6 HPA; HPA054111; - HPA; HPA076894; - MIM; 605976; gene neXtProt; NX_Q15916; - OpenTargets; ENSG00000186130; - PharmGKB; PA134939601; - eggNOG; KOG1721; Eukaryota eggNOG; COG5048; LUCA GeneTree; ENSGT00760000119063; - HOGENOM; HOG000232051; - HOVERGEN; HBG056199; - InParanoid; Q15916; - KO; K10493; - OMA; EKLPRHD; - OrthoDB; EOG091G04SQ; - PhylomeDB; Q15916; - TreeFam; TF333162; - SignaLink; Q15916; - GenomeRNAi; 10773; - PRO; PR:Q15916; - Proteomes; UP000005640; Chromosome 9 Bgee; ENSG00000186130; - CleanEx; HS_ZBTB6; - Genevisible; Q15916; HS GO; GO:0005739; C:mitochondrion; IDA:HPA GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0003677; F:DNA binding; TAS:ProtInc GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW InterPro; IPR000210; BTB/POZ_dom InterPro; IPR011333; SKP1/BTB/POZ_sf InterPro; IPR036236; Znf_C2H2_sf InterPro; IPR013087; Znf_C2H2_type Pfam; PF00651; BTB; 1 SMART; SM00225; BTB; 1 SMART; SM00355; ZnF_C2H2; 4 SUPFAM; SSF54695; SSF54695; 1 SUPFAM; SSF57667; SSF57667; 2 PROSITE; PS50097; BTB; 1 PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4 PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4 1: Evidence at protein level; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger CHAIN 1 424 Zinc finger and BTB domain-containing protein 6 /FTId=PRO_0000047608 DOMAIN 33 97 BTB. {ECO:0000255|PROSITE- ProRule:PRU00037} ZN_FING 301 323 C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042} ZN_FING 326 348 C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042} ZN_FING 354 376 C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042} ZN_FING 382 405 C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042} MOD_RES 202 202 Phosphoserine SEQUENCE 424 AA; 48236 MW; 304AE4BCAE62A3BC CRC64; MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNNQHT DLCQSSDPDV KNEDENSDKD CEIIEISEDS PVNIDFHVKE EESNALQSTV ESLTSERKEM KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT SSKASMYFSE TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG IRPFQCTVCL KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH LTSVHGRSSG EKLSRPDLKR QSLL
Citations (0)

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Background

ZBTB6 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB6, also known as ZNF482, is highly expressed in brain. While little is known about ZBTB6, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB family member, ZBTB5, also acts as a transcriptional repressor, and can interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, suggesting that ZBTB6 may also act as a transcriptional repressor.

References

Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. USA2002; 99:16899-903.
Filion GJP, Zhenilo S, Salozhin S, et al. A family of zinc finger proteins that bind methylated DNA and repress transcription. Mol. Cell. Biol.2006; 26:169-81.
Koh D, Choi W, Jeon B, et al. A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene. J. Biol. Chem.2009; 284:19856-66.

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$ 330.00
Cat# ASC11263
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