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ZMYM1 Antibody

     
  • WB - ZMYM1 Antibody ASC11267
    Western blot analysis of ZMYM1 in rat lung tissue lysate with ZMYM1 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - ZMYM1 Antibody ASC11267
    Immunohistochemistry of ZMYM1 in rat lung tissue with ZMYM1 antibody at 5 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q5SVZ6
Other Accession NP_079048, 113205089
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes ZMYM1 antibody can be used for detection of ZMYM1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 79830
Target/Specificity ZMYM1; At least two isoforms of ZMYM1 are known to exist; this antibody will detect only the shorter isoform. ZMYM1 antibody is predicted to not cross-react with other ZMYM protein family members.
Reconstitution & Storage ZMYM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZMYM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZMYM1
Cellular Location Nucleus. EMBL; BX537537; CAD97777.1; -; mRNA EMBL; AL607089; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471059; EAX07428.1; -; Genomic_DNA EMBL; CH471059; EAX07430.1; -; Genomic_DNA CCDS; CCDS41302.1; - RefSeq; NP_001276017.1; NM_001289088.1 RefSeq; NP_001276018.1; NM_001289089.1 RefSeq; NP_001276019.1; NM_001289090.1 RefSeq; NP_001306884.1; NM_001319955.1 RefSeq; NP_079048.3; NM_024772.4 UniGene; Hs.471243; - ProteinModelPortal; Q5SVZ6; - SMR; Q5SVZ6; - BioGrid; 122922; 39 IntAct; Q5SVZ6; 26 STRING; 9606.ENSP00000352920; - iPTMnet; Q5SVZ6; - PhosphoSitePlus; Q5SVZ6; - BioMuta; ZMYM1; - DMDM; 74743897; - EPD; Q5SVZ6; - MaxQB; Q5SVZ6; - PaxDb; Q5SVZ6; - PeptideAtlas; Q5SVZ6; - PRIDE; Q5SVZ6; - ProteomicsDB; 63955; - Ensembl; ENST00000359858; ENSP00000352920; ENSG00000197056 Ensembl; ENST00000373330; ENSP00000362427; ENSG00000197056 Ensembl; ENST00000611874; ENSP00000482579; ENSG00000197056 GeneID; 79830; - KEGG; hsa:79830; - UCSC; uc001bym.5; human CTD; 79830; - EuPathDB; HostDB:ENSG00000197056.9; - GeneCards; ZMYM1; - H-InvDB; HIX0000408; - HGNC; HGNC:26253; ZMYM1 HPA; HPA064019; - neXtProt; NX_Q5SVZ6; - OpenTargets; ENSG00000197056; - PharmGKB; PA134948969; - eggNOG; ENOG410IXK1; Eukaryota eggNOG; ENOG410XQ1Y; LUCA GeneTree; ENSGT00920000149037; - HOGENOM; HOG000132949; - HOVERGEN; HBG076163; - InParanoid; Q5SVZ6; - OMA; KWNEPLN; - OrthoDB; EOG091G01OH; - PhylomeDB; Q5SVZ6; - TreeFam; TF330114; - ChiTaRS; ZMYM1; human GenomeRNAi; 79830; - PRO; PR:Q5SVZ6; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000197056; - CleanEx; HS_ZMYM1; - ExpressionAtlas; Q5SVZ6; baseline and differential Genevisible; Q5SVZ6; HS GO; GO:0005737; C:cytoplasm; IBA:GO_Central GO; GO:0005654; C:nucleoplasm; IBA:GO_Central GO; GO:0003677; F:DNA binding; IBA:GO_Central GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central GO; GO:0008270; F:zinc ion binding; IEA:InterPro InterPro; IPR025398; DUF4371 InterPro; IPR008906; HATC_C_dom InterPro; IPR012337; RNaseH-like_sf InterPro; IPR011017; TRASH_dom InterPro; IPR010507; Znf_MYM Pfam; PF05699; Dimer_Tnp_hAT; 1 Pfam; PF14291; DUF4371; 1 Pfam; PF06467; zf-FCS; 2 SMART; SM00746; TRASH; 5 SUPFAM; SSF53098; SSF53098; 2 1: Evidence at protein level; Complete proteome; Isopeptide bond; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Zinc; Zinc-finger CHAIN 1 1142 Zinc finger MYM-type protein 1 /FTId=PRO_0000191377 ZN_FING 110 148 MYM-type 1 ZN_FING 160 203 MYM-type 2 ZN_FING 210 245 MYM-type 3 ZN_FING 300 331 MYM-type 4 ZN_FING 452 538 TTF-type COMPBIAS 384 420 Ser-rich CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) CROSSLNK 284 284 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) VARIANT 73 73 V -> M (in dbSNP:rs2971408) {ECO:0000269|PubMed:17974005, ECO:0000269|Ref.3} /FTId=VAR_034589 VARIANT 454 454 R -> Q (in dbSNP:rs7552714) /FTId=VAR_053767 VARIANT 493 493 E -> G (in dbSNP:rs16837197) /FTId=VAR_053768 SEQUENCE 1142 AA; 128717 MW; C8F1197AB842C3E4 CRC64; MKEPLLGGEC DKAVASQLGL LDEIKTEPDN AQEYCHRQQS RTQENELKIN AVFSESASQL TAGIQLSLAS SGVNKMLPSV STTAIQVSCA GCKKILQKGQ TAYQRKGSAQ LFCSIPCITE YISSASSPVP SKRTCSNCSK DILNPKDVIS VQLEDTTSCK TFCSLSCLSS YEEKRKPFVT ICTNSILTKC SMCQKTAIIQ YEVKYQNVKH NLCSNACLSK FHSANNFIMN CCENCGTYCY TSSSLSHILQ MEGQSHYFNS SKSITAYKQK PAKPLISVPC KPLKPSDEMI ETTSDLGKTE LFCSINCFSA YSKAKMESSS VSVVSVVHDT STELLSPKKD TTPVISNIVS LADTDVALPI MNTDVLQDTV SSVTATADVI VDLSKSSPSE PSNAVASSST EQPSVSPSSS VFSQHAIGSS TEVQKDNMKS MKISDELCHP KCTSKVQKVK GKSRSIKKSC CADFECLENS KKDVAFCYSC QLFCQKYFSC GRESFATHGT SNWKKTLEKF RKHEKSEMHL KSLEFWREYQ FCDGAVSDDL SIHSKQIEGN KKYLKLIIEN ILFLGKQCLP LRGNDQSVSS VNKGNFLELL EMRAKDKGEE TFRLMNSQVD FYNSTQIQSD IIEIIKTEML QDIVNEINDS SAFSIICDET INSAMKEQLS ICVRYPQKSS KAILIKERFL GFVDTEEMTG THLHRTIKTY LQQIGVDMDK IHGQAYDSTT NLKIKFNKIA AEFKKEEPRA LYIHCYAHFL DLSIIRFCKE VKELRSALKT LSSLFNTICM SGEMLANFRN IYRLSQNKTC KKHISQSCWT VHDRTLLSVI DSLPEIIETL EVIASHSSNT SFADELSHLL TLVSKFEFVF CLKFLYRVLS VTGILSKELQ NKTIDIFSLS SKIEAILECL SSERNDVYFK TIWDGTEEIC QKITCKGFKV EKPSLQKRRK IQKSVDLGNS DNMFFPTSTE EQYKINIYYQ GLDTILQNLK LCFSEFDYCK IKQISELLFK WNEPLNETTA KHVQEFYKLD EDIIPELRFY RHYAKLNFVI DDSCINFVSL GCLFIQHGLH SNIPCLSKLL YIALSWPITS ASTENSFSTL PRLKTYLCNT MGQEKLTGPA LMAVEQELVN KLMEPERLNE IVEKFISQMK EI
Citations (0)

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Background

ZMYM1 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role.

References

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21.
Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet.2000; 89:24-8.
Gocke CB and Yu H. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One2008; 3:e3255.

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$ 330.00
Cat# ASC11267
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