|Application ||WB, IF, E|
|Other Accession||AAH69057, 119625706|
|Calculated MW||152379 Da|
|Application Notes||ZMYM3 antibody can be used for detection of ZMYM3 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||ZMYM3; At least three isoforms of ZMYM3 are known to exist; this antibody will detect all three. ZMYM3 antibody is predicted to not cross-react with other ZMYM protein family members.|
|Reconstitution & Storage||ZMYM3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ZMYM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DXS6673E, KIAA0385, ZNF261|
|Function||Plays a role in the regulation of cell morphology and cytoskeletal organization.|
|Tissue Location||Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta|
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Provided below are standard protocols that you may find useful for product applications.
ZMYM3 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM3 is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation.
Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21
Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet.2000; 89:24-8.
van der Maarel SM, Scholten IH, Huber I, et al. Cloning and characterization of DSX6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum. Mol. Gen.1996; 5:887-97.
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