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ZMYM3 Antibody

     
  • WB - ZMYM3 Antibody ASC11269
    Western blot analysis of ZMYM3 in human brain tissue lysate with ZMYM3 antibody at 1 µg/mL.
    detail
  • IF - ZMYM3 Antibody ASC11269
    Immunofluorescence of ZMYM3 in human brain tissue with ZMYM3 antibody at 20 µg/mL.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession Q14202
Other Accession AAH69057, 119625706
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 152379 Da
Application Notes ZMYM3 antibody can be used for detection of ZMYM3 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 9203
Target/Specificity ZMYM3; At least three isoforms of ZMYM3 are known to exist; this antibody will detect all three. ZMYM3 antibody is predicted to not cross-react with other ZMYM protein family members.
Reconstitution & Storage ZMYM3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZMYM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZMYM3
Synonyms DXS6673E, KIAA0385, ZNF261
Function Plays a role in the regulation of cell morphology and cytoskeletal organization.
Cellular Location Nucleus.
Tissue Location Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta
Citations (0)
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Background

ZMYM3 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM3 is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation.

References

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21
Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet.2000; 89:24-8.
van der Maarel SM, Scholten IH, Huber I, et al. Cloning and characterization of DSX6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum. Mol. Gen.1996; 5:887-97.

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$ 379.00
Cat# ASC11269
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