|Application ||IHC-P, E|
|Other Accession||AAI27114, 117558167|
|Calculated MW||167 kDa|
|Application Notes||ZMYM4 antibody can be used for detection of ZMYM4 by immunohistochemistry at 5 µg/mL.|
|Target/Specificity||ZMYM4; At least three isoforms of ZMYM4 are known to exist; this antibody will detect all of them. ZMYM4 antibody is predicted not to cross-react with other ZMYM family members.|
|Reconstitution & Storage||ZMYM4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ZMYM4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of cell morphology and cytoskeletal organization.|
|Tissue Location||Expressed at higher level in heart, skeletal muscle, kidney and liver.|
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Provided below are standard protocols that you may find useful for product applications.
ZMYM4 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. It has been found to be overexpressed in human lung adenocarcinomas and squamous cell carcinomas, and the overexpression of a fragment of the 3'UTR of the ZMYM4 mRNA termed Cell Death Inhibiting RNA (CDIR) protects HeLa cells from IFN-γ-induced apoptosis, suggesting that ZMYM4 may play a role in tumorigenesis.
Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.
Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature 2006; 441:315-21.
Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet. 2000; 89:24-8.
McDoniels-Silvers AL, Nimri CF, Stoner GD, et al. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin. Cancer Res. 2002; 8:1127-38.
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