|Application ||WB, IHC-P, IF, E|
|Other Accession||AAH45113, 86990456|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||58641 Da|
|Application Notes||LRRTM1 antibody can be used for detection of LRRTM1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||LRRTM1; LRRTM1 antibody is predicted to not cross-react with other LRRTM family members.|
|Reconstitution & Storage||LRRTM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||LRRTM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in forebrain regions including thalamus and cerebral cortex|
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Provided below are standard protocols that you may find useful for product applications.
LRRTM1 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM1 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.
Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.
Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.
Haines BP and Rigby PW. Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr. Patterns 2007; 7:23-9.
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