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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RABEX5 Antibody   

RABEX5 Antibody

  • WB - RABEX5 Antibody ASC11295
    Western blot analysis of RABEX5 in human liver tissue lysate with RABEX5 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - RABEX5 Antibody ASC11295
    Immunohistochemistry of RABEX5 in mouse brain tissue with RABEX5 antibody at 5 µg/mL.
  • IF - RABEX5 Antibody ASC11295
    Immunofluorescence of RABEX5 in mouse brain tissue with RABEX5 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UJ41
Other Accession NP_055319, 7657496
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 79371 Da
Application Notes RABEX5 antibody can be used for detection of RABEX5 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 27342
Target/Specificity RABGEF1; At least four isoforms of RABEX5 are known to exist; this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.
Reconstitution & Storage RABEX5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsRABEX5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RABEX5
Function Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).
Cellular Location Cytoplasm. Early endosome. Recycling endosome
Research Areas
Citations (0)

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RABEX5 Antibody: RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.


Horiuchi H, Lippe R, McBride HM, et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 1997; 90:1149-59.
Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.

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$ 310.00
Cat# ASC11295
(40 western blots)
Availability: 5-7days
Bulk Size
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