|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_001093859, 154240704|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||30922 Da|
|Application Notes||TMEM192 antibody can be used for detection of TMEM192 by Western blot at 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||TMEM192; At least two isoforms of TMEM192 are known to exist; this antibody will recognize both. TMEM192 antibody is predicted to not cross-react with other TMEM proteins.|
|Reconstitution & Storage||TMEM192 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||TMEM192 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein. Late endosome|
|Tissue Location||Strongly expressed in kidney, liver, lung and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
TMEM192 Antibody: TMEM192 is a widely expressed, four transmembrane protein that localizes to late endosomal/lysosomal membranes. This localization is mediated by two dileucine motifs present at the amino-terminus of TMEM192. A cysteine residue near the carboxy residue is responsible for disulfide bond formation in TMEM192 homodimers. Little is known about the function of this protein.
Schroder B, Wrocklage C, Hasilik A, et al. Molecular characterisation of ‘transmembrane protein 192'(TMEM192, a novel protein of the lysosomal membrane. Biol. Chem. 2010; 391:695-704.
Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.
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