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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SYTL5 Antibody   

SYTL5 Antibody

     
  • WB - SYTL5 Antibody ASC11352
    Western blot analysis of SYTL5 in Hela cell lysate with SYTL5 antibody at (A) 1 and (B) 2 µg/mL .
  • IHC - SYTL5 Antibody ASC11352
    Immunohistochemistry of SYTL2 in rat liver tissue with SYTL2 antibody at 5 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8TDW5
Other Accession NP_620135, 254039650
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes SYTL5 antibody can be used for detection of SYTL5 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 94122
Target/Specificity SYTL5; Multiple isoforms of SYTL5 are known to exist. SYTL5 antibody is predicted to not cross-react with other SYTL protein family members.
Reconstitution & Storage SYTL5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSYTL5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYTL5
Synonyms SLP5
Function May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Cellular Location Membrane; Peripheral membrane protein
Tissue Location Highly expressed in placenta and liver. EMBL; AB080222; BAB88906.1; -; mRNA EMBL; AL121578; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC131585; AAI31586.1; -; mRNA CCDS; CCDS14244.1; -. [Q8TDW5-1] CCDS; CCDS55399.1; -. [Q8TDW5-2] RefSeq; NP_001156806.1; NM_001163334.1. [Q8TDW5-2] RefSeq; NP_001156807.1; NM_001163335.1. [Q8TDW5-1] RefSeq; NP_620135.1; NM_138780.2. [Q8TDW5-1] RefSeq; XP_011542303.1; XM_011544001.2. [Q8TDW5-2] RefSeq; XP_011542304.1; XM_011544002.2. [Q8TDW5-2] RefSeq; XP_016885461.1; XM_017029972.1. [Q8TDW5-2] RefSeq; XP_016885462.1; XM_017029973.1. [Q8TDW5-2] RefSeq; XP_016885463.1; XM_017029974.1. [Q8TDW5-2] UniGene; Hs.662334; - ProteinModelPortal; Q8TDW5; - SMR; Q8TDW5; - BioGrid; 125121; 7 IntAct; Q8TDW5; 9 STRING; 9606.ENSP00000395220; - iPTMnet; Q8TDW5; - PhosphoSitePlus; Q8TDW5; - BioMuta; SYTL5; - DMDM; 33301662; - MaxQB; Q8TDW5; - PaxDb; Q8TDW5; - PeptideAtlas; Q8TDW5; - PRIDE; Q8TDW5; - ProteomicsDB; 74354; - ProteomicsDB; 74355; -. [Q8TDW5-2] Ensembl; ENST00000297875; ENSP00000297875; ENSG00000147041. [Q8TDW5-1] Ensembl; ENST00000456733; ENSP00000395220; ENSG00000147041. [Q8TDW5-2] GeneID; 94122; - KEGG; hsa:94122; - UCSC; uc004ddv.4; human. [Q8TDW5-1] CTD; 94122; - DisGeNET; 94122; - EuPathDB; HostDB:ENSG00000147041.11; - GeneCards; SYTL5; - HGNC; HGNC:15589; SYTL5 HPA; HPA026074; - neXtProt; NX_Q8TDW5; - OpenTargets; ENSG00000147041; - PharmGKB; PA37988; - eggNOG; ENOG410IT3S; Eukaryota eggNOG; ENOG410Y1U8; LUCA GeneTree; ENSGT00810000125376; - HOGENOM; HOG000231332; - HOVERGEN; HBG054255; - InParanoid; Q8TDW5; - KO; K17598; - OMA; ETGDYGN; - OrthoDB; EOG091G07OO; - PhylomeDB; Q8TDW5; - TreeFam; TF341184; - GenomeRNAi; 94122; - PRO; PR:Q8TDW5; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000147041; - CleanEx; HS_SYTL5; - Genevisible; Q8TDW5; HS GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central GO; GO:0005886; C:plasma membrane; IBA:GO_Central GO; GO:0098793; C:presynapse; IEA:GOC GO; GO:0005509; F:calcium ion binding; IBA:GO_Central GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central GO; GO:0030276; F:clathrin binding; IBA:GO_Central GO; GO:0017137; F:Rab GTPase binding; IEA:InterPro GO; GO:0019905; F:syntaxin binding; IBA:GO_Central GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central GO; GO:0006886; P:intracellular protein transport; IEA:InterPro GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IBA:GO_Central GO; GO:0006906; P:vesicle fusion; IBA:GO_Central CDD; cd04029; C2A_SLP-4_5; 1 Gene3D; 2.60.40.150; -; 2 Gene3D; 3.30.40.10; -; 1 InterPro; IPR000008; C2_dom InterPro; IPR035892; C2_domain_sf InterPro; IPR010911; Rab_BD InterPro; IPR037303; SLP-4/5_C2A InterPro; IPR028702; Slp5 InterPro; IPR011011; Znf_FYVE_PHD InterPro; IPR013083; Znf_RING/FYVE/PHD PANTHER; PTHR10024:SF13; PTHR10024:SF13; 1 Pfam; PF00168; C2; 2 SMART; SM00239; C2; 2 SUPFAM; SSF57903; SSF57903; 1 PROSITE; PS50004; C2; 2 PROSITE; PS50916; RABBD; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger CHAIN 1 730 Synaptotagmin-like protein 5 /FTId=PRO_0000190219 DOMAIN 7 123 RabBD. {ECO:0000255|PROSITE- ProRule:PRU00234} DOMAIN 408 511 C2 1. {ECO:0000255|PROSITE- ProRule:PRU00041} DOMAIN 574 678 C2 2. {ECO:0000255|PROSITE- ProRule:PRU00041} ZN_FING 64 106 FYVE-type MOD_RES 147 147 Phosphoserine {ECO:0000250|UniProtKB:Q80T23} VAR_SEQ 384 384 S -> STSSQAGSDRKWTYLNVPDADSD (in isoform 2). /FTId=VSP_042659 VARIANT 275 275 I -> V (in dbSNP:rs4827331) /FTId=VAR_024601 VARIANT 302 302 R -> C (in dbSNP:rs57226394) /FTId=VAR_061753 SEQUENCE 730 AA; 81523 MW; D9E0DA98880A95ED CRC64; MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE QRLWQKMANN PGTPFEGVLM LRSSMGKCRL
Research Areas
Citations (0)

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Background

SYTL5 Antibody: SYTL5 belongs to the synaptotagmin-like (Slp) protein family, which contains a unique Slp homolog domain (SHD) at the N-terminus. The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of SYTL5 is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Several members of the synaptotagmin family are calcium-sensing vesicle-fusion proteins as mediators of cell migration. SYTL7 & SYTL5 were positive regulators of chemotaxis, whereas SYTL2 was a negative regulator of chemotaxis.

References

Kuroda TS, Fukuda M, Ariga H, et al. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem. Biophys. Res. Commun. 2002; 293:899-906.
Saxena SK, Horiuchi H, and Fukuda M. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Biochem. Biophys. Res. Commun. 2006; 344:651-7.
Colvin RA, Means TK, Diefenbach TJ, et al. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat. Immunol. 2010; 11:495-502
Fukuda M, Mikoshiba K. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem. Biophys. Res. Commun. 2001; 281:1226-33.

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$ 330.00
Cat# ASC11352
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