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SYTL5 Antibody

  • WB - SYTL5 Antibody ASC11352
    Western blot analysis of SYTL5 in Hela cell lysate with SYTL5 antibody at (A) 1 and (B) 2 µg/mL .
  • IHC - SYTL5 Antibody ASC11352
    Immunohistochemistry of SYTL2 in rat liver tissue with SYTL2 antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDW5
Other Accession NP_620135, 254039650
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 81523 Da
Application Notes SYTL5 antibody can be used for detection of SYTL5 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 94122
Target/Specificity SYTL5; Multiple isoforms of SYTL5 are known to exist. SYTL5 antibody is predicted to not cross-react with other SYTL protein family members.
Reconstitution & Storage SYTL5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSYTL5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYTL5
Synonyms SLP5
Function May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Cellular Location Membrane; Peripheral membrane protein
Tissue Location Highly expressed in placenta and liver.
Research Areas
Citations (0)

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SYTL5 Antibody: SYTL5 belongs to the synaptotagmin-like (Slp) protein family, which contains a unique Slp homolog domain (SHD) at the N-terminus. The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of SYTL5 is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Several members of the synaptotagmin family are calcium-sensing vesicle-fusion proteins as mediators of cell migration. SYTL7 & SYTL5 were positive regulators of chemotaxis, whereas SYTL2 was a negative regulator of chemotaxis.


Kuroda TS, Fukuda M, Ariga H, et al. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem. Biophys. Res. Commun. 2002; 293:899-906.
Saxena SK, Horiuchi H, and Fukuda M. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Biochem. Biophys. Res. Commun. 2006; 344:651-7.
Colvin RA, Means TK, Diefenbach TJ, et al. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat. Immunol. 2010; 11:495-502
Fukuda M, Mikoshiba K. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem. Biophys. Res. Commun. 2001; 281:1226-33.

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$ 320.00
Cat# ASC11352
Availability: 5-7days
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