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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TMEM59L Antibody   

TMEM59L Antibody

  • WB - TMEM59L Antibody ASC11356
    Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 µg/mL.
  • IHC - TMEM59L Antibody ASC11356
    Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 µg/mL.
  • IF - TMEM59L Antibody ASC11356
    Immunofluorescence of TMEM59L in mouse brain tissue with TMEM59L antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UK28
Other Accession NP_036241, 6912274
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 37619 Da
Application Notes TMEM59L antibody can be used for detection of TMEM59L by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 25789
Target/Specificity TMEM59L; Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.
Reconstitution & Storage TMEM59L antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTMEM59L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM59L
Synonyms BSMAP, C19orf4
Function Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
Cellular Location Golgi apparatus membrane; Single-pass type I membrane protein
Tissue Location Expressed preferentially at high level in the brain
Research Areas
Citations (0)

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TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.


Schöbel S, Neumann S, Seed B, et al. Expression cloning screen for modifiers of amyloid precursor protein shedding. Int. J. Dev. Neurosci. 2006; 24:141-8.
Schöbel S, Neumann S, Hertweck M, et al. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 2008; 283:14257-68.
Elson GC, de Coignac AB, Aubry JP, et al. BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. Biochem. Biophys. Res. Commun. 1999; 264:55-62.
Ullrich S, Münch A, Neumann S, et al. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 2010; 285:20664-74.

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$ 310.00
Cat# ASC11356
(40 western blots)
Availability: 5-7days
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