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LY6K Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q17RY6 |
| Other Accession | EAW82311, 237820711 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 18673 Da |
| Application Notes | LY6K antibody can be used for detection of LY6K by Western blot at 1 - 2 µg/mL. |
| Gene ID | 54742 |
|---|---|
| Target/Specificity | LY6K; Multiple isoforms of LY6K are known to exist. |
| Reconstitution & Storage | LY6K antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | LY6K Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LY6K (HGNC:24225) |
|---|---|
| Synonyms | CO16 {ECO:0000303|Ref.1} |
| Function | Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth (PubMed:18089789). |
| Cellular Location | Secreted. Cytoplasm. Cell membrane {ECO:0000250|UniProtKB:Q9CWP4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9CWP4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9CWP4}. Membrane raft {ECO:0000250|UniProtKB:Q9CWP4} |
| Tissue Location | Specifically expressed in testis (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
LY6K Antibody: The lymphocyte antigen 6 complex locus K (LY6K), a member of cancer-testis antigen was initially identified as a molecular marker for head-and-neck squamous cell carcinoma as well a breast cancer. LY6K is a GPI-anchored membrane protein that is specifically associated with germ cell marker TEX101 and is strongly observed in testis, but only weakly in other tissues. LY6K mRNA was found to be upregulated in numerous bladder cancers due to gene amplification. Furthermore, knockdown experiments using LY6K siRNA reduced cell growth, migration and invasion in bladder carcinoma cell lines, suggesting that LY6K contributes to bladder cancer development.
References
de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, et al. Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma. Int. J. Cancer 2003; 103:768-74.
Lee JW, Lee YS, Yoo KH, et al. LY-6K gene: a novel molecular marker for human breast cancer. Oncol. Rep. 2006; 16:1211-4.
Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, et al. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus K within the mouse testis. Biochem. Biophys. Res. Commun. 2008; 372:277-82.
Maruyama M, Yoshitake H, Tsukamoto H, et al. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem. Biophys. Res. Commun. 2010; 402:75-81.
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