|Application ||WB, E|
|Other Accession||NP_079527, 58331179|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||121286 Da|
|Application Notes||ARHGAP39 antibody can be used for detection of ARHGAP39 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||ARHGAP39; ARHGAP39 antibody is predicted to not cross-react with other RhoGAP protein family members.|
|Reconstitution & Storage||ARHGAP39 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ARHGAP39 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
ARHGAP39 Antibody: Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP39 (Rho GTPase activating protein 39) is a 1, 083 amino acid nuclear protein that contains one MyTH4 domain, one Rho GAP domain and two WW domains. It is encoded by a gene located on human chromosome 8, which is associated with a variety of diseases and malignancies. ARHGAP39 regulates robo signaling and plays important roles in axon guidance.
Takai Y, Sasaki T, and Matozaki T. Small GTP-binding proteins. Physiol. Rev. 2001; 81:153-208.
Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc. Natl. Acad. Sci. USA 2005; 102:4613-8
Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature 2006; 439:331-5
Lundström A, Gallio M, Englund C, et al. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 2004; 18:2161-71.
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