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ARHGAP39 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9C0H5 |
| Other Accession | NP_079527, 58331179 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 121286 Da |
| Application Notes | ARHGAP39 antibody can be used for detection of ARHGAP39 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 80728 |
|---|---|
| Target/Specificity | ARHGAP39; ARHGAP39 antibody is predicted to not cross-react with other RhoGAP protein family members. |
| Reconstitution & Storage | ARHGAP39 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | ARHGAP39 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGAP39 |
|---|---|
| Synonyms | KIAA1688 |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARHGAP39 Antibody: Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP39 (Rho GTPase activating protein 39) is a 1, 083 amino acid nuclear protein that contains one MyTH4 domain, one Rho GAP domain and two WW domains. It is encoded by a gene located on human chromosome 8, which is associated with a variety of diseases and malignancies. ARHGAP39 regulates robo signaling and plays important roles in axon guidance.
References
Takai Y, Sasaki T, and Matozaki T. Small GTP-binding proteins. Physiol. Rev. 2001; 81:153-208.
Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc. Natl. Acad. Sci. USA 2005; 102:4613-8
Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature 2006; 439:331-5
Lundström A, Gallio M, Englund C, et al. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 2004; 18:2161-71.
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