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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Coronin 7 Antibody   

Coronin 7 Antibody

  • WB - Coronin 7 Antibody ASC11364
    Western blot analysis of Coronin 7 in rat lung tissue lysate with Coronin 7 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - Coronin 7 Antibody ASC11364
    Immunohistochemistry of Coronin 7 in rat lung tissue with Coronin 7 antibody at 2.5 µg/mL.
  • IF - Coronin 7 Antibody ASC11364
    Immunofluorescence of Coronin 7 in rat lung tissue with Coronin 7 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P57737
Other Accession NP_078811, 168229161
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 100605 Da
Application Notes Coronin 7 antibody can be used for detection of Coronin 7 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 79585
Target/Specificity CORO7; Multiple isoforms of Coronin 7 are known to exist
Reconstitution & Storage Coronin 7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCoronin 7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CORO7
Function F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post- Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Cellular Location Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments
Tissue Location Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine
Research Areas
Citations (0)

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Coronin 7 Antibody: Coronins, such as Coronin 7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins whose function is thought to be regulating the cytoskeleton. Unlike other cytoplasmically localized Coronins, Coronin 7 localizes in part to the Golgi complex and is thought to play a role in Golgi complex morphology and function. Other experiments indicate that Coronin 7 interacts with the anti-proliferative protein TOB1 and enhances its degradation though the SCF ubiquitin ligase (E3) complex.


Rybakin V, Stumpf N, Schulze A, et al. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. FEBS Lett. 2004; 573:161-7.
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. J. Biol. Chem. 2006; 281:31070-8.
Watanabe M, Suzuki T, Kim M, et al. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 2011; 585:65-70.

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$ 330.00
Cat# ASC11364
Availability: 5-7days
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