Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Cancer   >   HIG2 Antibody   

HIG2 Antibody

  • WB - HIG2 Antibody ASC11376
    Western blot analysis of HIG2 in 3T3 cell lysate with HIG2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BW72
Other Accession NP_001092256, 20270389
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes HIG2 antibody can be used for detection of HIG2 by Western blot at 1 µg/mL.
Additional Information
Gene ID 192286
Target/Specificity HIGD2A; At least two isoforms of HIG2 are known to exist; this antibody will detect both isoforms. HIG2 antibody is predicted to not cross-react with HIG1
Reconstitution & Storage HIG2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsHIG2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.
Cellular Location Mitochondrion membrane {ECO:0000255|PROSITE- ProRule:PRU00836, ECO:0000269|PubMed:22342701}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836, ECO:0000269|PubMed:22342701}. Mitochondrion inner membrane EMBL; BC000587; -; NOT_ANNOTATED_CDS; mRNA EMBL; BC007502; AAH07502.1; -; mRNA CCDS; CCDS4401.1; - RefSeq; NP_620175.1; NM_138820.3 UniGene; Hs.534575; - UniGene; Hs.696283; - ProteinModelPortal; Q9BW72; - SMR; Q9BW72; - BioGrid; 128172; 8 IntAct; Q9BW72; 5 iPTMnet; Q9BW72; - PhosphoSitePlus; Q9BW72; - SwissPalm; Q9BW72; - BioMuta; HIGD2A; - DMDM; 74733402; - EPD; Q9BW72; - MaxQB; Q9BW72; - PaxDb; Q9BW72; - PeptideAtlas; Q9BW72; - PRIDE; Q9BW72; - ProteomicsDB; 79260; - TopDownProteomics; Q9BW72; - DNASU; 192286; - Ensembl; ENST00000274787; ENSP00000274787; ENSG00000146066 GeneID; 192286; - KEGG; hsa:192286; - UCSC; uc003meg.4; human CTD; 192286; - DisGeNET; 192286; - EuPathDB; HostDB:ENSG00000146066.2; - GeneCards; HIGD2A; - H-InvDB; HIX0005440; - H-InvDB; HIX0038135; - HGNC; HGNC:28311; HIGD2A HPA; HPA042715; - neXtProt; NX_Q9BW72; - PharmGKB; PA142671685; - eggNOG; KOG4431; Eukaryota eggNOG; ENOG41121ET; LUCA GeneTree; ENSGT00910000144291; - HOGENOM; HOG000234513; - HOVERGEN; HBG054361; - InParanoid; Q9BW72; - OMA; HRGQSQR; - OrthoDB; EOG091G166Q; - PhylomeDB; Q9BW72; - TreeFam; TF314628; - ChiTaRS; HIGD2A; human GenomeRNAi; 192286; - PRO; PR:Q9BW72; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000146066; - CleanEx; HS_HIGD2A; - ExpressionAtlas; Q9BW72; baseline and differential Genevisible; Q9BW72; HS GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; IDA:MGI GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW InterPro; IPR007667; Hypoxia_induced_domain Pfam; PF04588; HIG_1_N; 1 PROSITE; PS51503; HIG1; 1 1: Evidence at protein level; Acetylation; Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix; Transport INIT_MET 1 1 Removed. CHAIN 2 106 HIG1 domain family member 2A, mitochondrial /FTId=PRO_0000215777 TRANSMEM 47 67 Helical. {ECO:0000255|PROSITE- ProRule:PRU00836} TRANSMEM 83 103 Helical. {ECO:0000255|PROSITE- ProRule:PRU00836} TOPO_DOM 104 106 Mitochondrial matrix. DOMAIN 20 106 HIG1. {ECO:0000255|PROSITE- ProRule:PRU00836} MOD_RES 2 2 N-acetylalanine SEQUENCE 106 AA; 11529 MW; 205DE0AE39950053 CRC64; MATPGPVIPE VPFEPSKPPV IEGLSPTVYR NPESFKEKFV RKTRENPVVP IGCLATAAAL TYGLYSFHRG NSQRSQLMMR TRIAAQGFTV AAILLGLAVT AMKSRP
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


HIG2 Antibody: HIG1 and HIG2 (Hypoxia-inducible gene 1 and 2, respectively) are known to be induced by hypoxic conditions. HIG2 is induced by hypoxia and by glucose deprivation in cultured cells. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Unlike HIG2, which is ubiquitously expressed and might be an activator and target of the canonical Wnt pathway, the function and the mechanisms underlying its regulation of HIG1 still remained unknown. The putative link between hypoxia and an oncogenic signaling pathway might play an important role in tumorigenesis.


Bedo G, Vargas M, Ferreiro MJ, et al. Characterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression. Int. J. Dev. Biol. 2005; 49:431-6
Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep. 2000; 1:287-92
Denko NC, Schindler C, Koong A, et al. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin. Cancer Res. 2000; 6:480-7
Gimm T, Wiese M, Teschemacher B, et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010; 24:4443-58.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 330.00
Cat# ASC11376
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
“Crown Flash”  50 % off on 2,500+ Crown Antibodies. PromoCode:<span class=text-red> FLASH50
Terms & Conditions