|Application ||WB, E|
|Other Accession||Q6ZMR5, 167466250|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||47569 Da|
|Application Notes||ECRG1 antibody can be used for detection of ECRG1 by Western blot at 1 µg/mL.|
|Target/Specificity||TMPRSS11A; At least two isoforms of ECRG1 are known to exist; ECRG1 antibody is predicted to not cross-react with other ECRG family members.|
|Reconstitution & Storage||ECRG1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ECRG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ECRG1, HATL1, HESP|
|Function||Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers|
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Provided below are standard protocols that you may find useful for product applications.
ECRG1 Antibody: Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.
Yueying W, Jianbo W, Hailin L, et al. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. Carcinogenesis 2008; 29:157-60.
Zhao N, Wang J, Cui Y, et al. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. J. Cell Biochem. 2004; 92:65-76
Zhao N, Huang G, Guo L, et al. ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. Exp. Biol. Med. 2006; 231:84-90.
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