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SPATA6 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9NWH7 |
| Other Accession | NP_061946, 9506603 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 55989 Da |
| Application Notes | SPATA6 antibody can be used for detection of SPATA6 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 54558 |
|---|---|
| Target/Specificity | SPATA6; At least three isoforms of SPATA6 are known to exist; this antibody will detect only the longest two isoforms. SPATA6 antibody is predicted to not cross-react with other SPATA protein family members. |
| Reconstitution & Storage | SPATA6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SPATA6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPATA6 |
|---|---|
| Function | Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q3U6K5}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q3U6K5} Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece. {ECO:0000250|UniProtKB:Q3U6K5} |
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Provided below are standard protocols that you may find useful for product applications.
Background
SPATA6 Antibody: The development of spermatogonial stem cells into spermatozoa, i.e., spermatogenesis, is a highly ordered process that requires multiple proteins, including some that are testis-specific or testis-specific isoforms of genes that are expressed in other tissues. One such protein is SPATA6: while its full-length isoform is expressed in multiple tissues including thymus, brain and testis, the shorter isoform is expressed only in testis. It has some homology to the motor domain of kinesin related proteins and with the C. elegans neural calcium sensor protein NCS-2.
References
Venables JP. Alternative splicing in the testes. Curr. Opin. Genet. Dev. 2002; 12:615-9.
Oh C, Aho H, Shamsadin R, et al. Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). Mol. Human Reprod. 2003; 9:321-30.
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