|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_071744, 23238238|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||26943 Da|
|Application Notes||MS4A6A antibody can be used for detection of MS4A6A by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||MS4A6A; At least three isoforms of MS4A6A are known to exist; this antibody will detect the two longer isoforms. MS4A6A antibody is predicted to not cross-react with MS4A family members.|
|Reconstitution & Storage||MS4A6A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||MS4A6A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||4SPAN3, CD20L3, MS4A6|
|Function||May be involved in signal transduction as a component of a multimeric receptor complex.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Variable expression in some B-cell, myelomonocytic, and erythroleukemia cell lines|
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Provided below are standard protocols that you may find useful for product applications.
MS4A6A Antibody: The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other genes encoding membrane proteins, most having characteristic tetraspanning topology and similar intron/exon splice boundaries. All family members display unique expression patterns among hematopoietic cells and non-lymphoid tissues. The function of MS4A6A has been suggested to be involved in signal transduction as a component of a multimeric receptor complex in Alzheimer's disease and cancer.
Liang Y and Tedder TF. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 2001; 72:119-27
Ishibashi K, Suzuki M, Sasaki S, et al. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 2001; 264:87-93.
Antúnez C, Boada M, Gonzalez-Pérez A, et al. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Med. 2011; 3:33
Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011; 43:429-35.
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