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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LEMD3 Antibody   

LEMD3 Antibody

  • WB - LEMD3 Antibody ASC11406
    Western blot analysis of LEMD3 in human colon tissue lysate with LEMD3 antibody at 1 µg/mL.
  • IHC - LEMD3 Antibody ASC11406
    Immunohistochemistry of LEMD3 in human colon tissue with LEMD3 antibody at 2.5 µg/mL.
  • IF - LEMD3 Antibody ASC11406
    Immunofluorescence of LEMD3 in human colon tissue with LEMD3 antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2U8
Other Accession NP_055134, 7706607
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 99997 Da
Application Notes LEMD3 antibody can be used for detection of LEMD3 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 5 µg/mL.
Additional Information
Gene ID 23592
Target/Specificity LEMD3; At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2
Reconstitution & Storage LEMD3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsLEMD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LEMD3
Synonyms MAN1
Function Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Cellular Location Nucleus inner membrane; Multi-pass membrane protein
Tissue Location Heart, brain, placenta, lung, liver and skeletal muscle
Research Areas
Citations (0)

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LEMD3 Antibody: LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.


Hellemans J, Preobrazhenska O, Willaert A, et al. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. Nat. Genet. 2004; 36:1213-8.

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$ 310.00
Cat# ASC11406
(40 western blots)
Availability: 5-7days
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