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ZGPAT Antibody

  • WB - ZGPAT Antibody ASC11410
    Western blot analysis of ZGPAT in SK-N-SH cell lysate with ZGPAT antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IF - ZGPAT Antibody ASC11410
    Immunofluorescence of ZGPAT in human brain cells with ZGPAT antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N5A5
Other Accession NP_115916, 133925793
Reactivity Human
Host Chicken
Clonality Polyclonal
Isotype IgY
Calculated MW 57359 Da
Application Notes ZGPAT antibody can be used for detection of ZGPAT by Western blot at 1 µg/mL. Antibody can also be used for immunofluorescence starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84619
Target/Specificity ZGPAT; Multiple isoforms of ZGPAT are known to exist.
Reconstitution & Storage ZGPAT antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZGPAT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC
Function Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
Cellular Location Nucleus.
Tissue Location Widely expressed.
Citations (0)

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ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.


Li R, Zhang H, Yu W, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009; 28:2763-6.
Yu W, Li R, Gui B, et al. sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP. J. Biol. Chem. 2010; 285:14301-7.

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$ 310.00
Cat# ASC11410
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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