|Application ||WB, E|
|Other Accession||EAW67810, 28376652|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||19186 Da|
|Application Notes||SPATA19 antibody can be used for detection of SPATA19 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||SPATA19; At least two isoforms of SPATA19 are known to exist; this antibody will detect both isoforms. SPATA19 antibody is predicted to not cross-react with other SPATA family members.|
|Reconstitution & Storage||SPATA19 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||SPATA19 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in spermiogenesis.|
|Cellular Location||Mitochondrion outer membrane.|
|Tissue Location||Expressed specifically in testis.|
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Provided below are standard protocols that you may find useful for product applications.
SPATA19 Antibody: SPATA19, also known as SPERGEN1, was initially identified as a testis-specific protein that localizes to the surface of mitochondria in the middle piece of mature spermatozoa. Recent experiments have shown that elevated levels of SPATA19 have been found in basal cell carcinomas and prostate cancers, suggesting that SPATA19 may serve as a putative cancer biomarker and a target for cancer immunotherapy.
Miyamoto T, Sengoku K, Hasuike S, et al. Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1. J. Assist. Reprod. Genet. 2003; 20:101-4.
Doiguchi M, Mori T, Toshimori K, et al. Spergen-1 might be an adhesive molecule associated with mitochondria in the middle piece of spermatozoa. Dev. Biol. 2002; 252:127-37.
Ghafouri-Fard S, Abbasi A, Moslehi H, et al. Elevated levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features. Br. J. Dermatol. 2010; 162:772-9
Ghafouri-Fard S, Ousati Ashtiani Z, Sabah Golian B, et al. Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer. Arch. Med. Res. 2010; 41:195-200.
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